Evaluation of the Evolution of Digital Nursing Interventions in an Emergency Unit: An Observational Study.

This study aimed to examine the influence of new ICTs on the recording of nursing interventions in the Emergency Unit of the High Resolution Hospital (HRH) of Loja (Granada), Spain. A descriptive observational study was conducted to analyze the evolution of the Nursing Interventions (NIC) records in the Emergency Unit of the Loja HRH (Granada) from 2017 to 2021. Results showed that 11,076 NIC registrations were exploited, which increased by 51.2% from 2017 to 2021. The linear correlation between the NIC and the years was analyzed with Spearman's coefficient, obtaining a low level of correlation (p = 0.166), but one that is statistically significant (p < 0.001). The introduction of tablet devices in the emergency room of the Loja HRH (Granada) led to a significant increase in the percentage of NIC recorded and collated during the study period without increasing the number of emergencies attended. However, usability barriers of ICTs were detected, highlighting the need to guide and train health professionals in their use and in the culture of patient safety.

Infectious complications of non-surgical biliary tract manipulation in paediatric patients. Role of antibiotic prophylaxis.

BACKGROUND: Infections related to non-surgical manipulation of the biliary tract (NSMBT) are common events despite periprocedural antibiotic prophylaxis (PAP). Since June 2017, our local protocol has indicated a 24-h regimen of intravenous piperacillin-tazobactam for this purpose. OBJECTIVE: We aimed to describe the incidence and characteristics of NSMBT-related paediatric infections, define risk factors for their development, and analyse adherence to our PAP protocol. MATERIALS AND METHODS: Epidemiological, clinical, and microbiological data were collected in consecutive NSMBT procedures performed in paediatric patients (<18 years) in our centre (2010-2019). RESULTS: 113 procedures in 37 patients, median age 4 years (IQR 1-8), were included. Main underlying diseases were biliary atresia (32%) and cancer (14%). Sixty-eight percent had undergone liver transplant and 70% hepaticojejunostomy. In 44 procedures (39%), the intervention was performed during the course of infection and previously prescribed antibiotic treatment was maintained. In the other 69, PAP was specifically indicated for NSMBT; antibiotic adequacy increased from 35% to 100% after June 2017. In total, 32 NSMBT-related infections (28%) occurred, mainly in the first 24h post-procedure (72%); no deaths happened. Causative pathogens were Gram-negative rods (64%), Gram-positive cocci (28%), and Candida spp. (8%). Main related risk factors were hepaticojejunostomy, biliary obstruction, and liver transplant. CONCLUSIONS: NSMBT in children entails a significant infection risk, even under antibiotic prophylaxis, being hepaticojejunostomy the main risk factor. Infectious complications mainly occurred immediately after the procedure. After establishing a PAP protocol, 100% of interventions received appropriate prophylaxis, decreasing antibiotic exposure time and potentially, the length of hospital stay.

Infectious complications of non-surgical biliary tract manipulation in paediatric patients. Role of antibiotic prophylaxis / Complicaciones infecciosas de la manipulación no quirúrgica de las vías biliares en pacientes pediátricos. Función de la profilaxis antibiótica

Background: Infections related to non-surgical manipulation of the biliary tract (NSMBT) are common events despite periprocedural antibiotic prophylaxis (PAP). Since June 2017, our local protocol has indicated a 24-h regimen of intravenous piperacillin–tazobactam for this purpose. Objective: We aimed to describe the incidence and characteristics of NSMBT-related paediatric infections, define risk factors for their development, and analyse adherence to our PAP protocol. Materials and methods: Epidemiological, clinical, and microbiological data were collected in consecutive NSMBT procedures performed in paediatric patients (<18 years) in our centre (2010–2019). Results: 113 procedures in 37 patients, median age 4 years (IQR 1–8), were included. Main underlying diseases were biliary atresia (32%) and cancer (14%). Sixty-eight percent had undergone liver transplant and 70% hepaticojejunostomy. In 44 procedures (39%), the intervention was performed during the course of infection and previously prescribed antibiotic treatment was maintained. In the other 69, PAP was specifically indicated for NSMBT; antibiotic adequacy increased from 35% to 100% after June 2017. In total, 32 NSMBT-related infections (28%) occurred, mainly in the first 24h post-procedure (72%); no deaths happened. Causative pathogens were Gram-negative rods (64%), Gram-positive cocci (28%), and Candida spp. (8%). Main related risk factors were hepaticojejunostomy, biliary obstruction, and liver transplant. Conclusions: NSMBT in children entails a significant infection risk, even under antibiotic prophylaxis, being hepaticojejunostomy the main risk factor. Infectious complications mainly occurred immediately after the procedure. After establishing a PAP protocol, 100% of interventions received appropriate prophylaxis, decreasing antibiotic exposure time and potentially, the length of hospital stay.(AU)

Antecedentes: Las infecciones relacionadas con la manipulación no quirúrgica de las vías biliares (MNQVB) son acontecimientos frecuentes, a pesar de la profilaxis antibiótica periprocedimiento (PAP). Desde junio de 2017, nuestro protocolo local indica una pauta de 24 h de piperacilina/tazobactam por vía intravenosa para este fin. Objetivo: El objetivo era describir la incidencia y las características de las infecciones pediátricas relacionadas con la MNQVB, definir los factores de riesgo para su desarrollo y analizar el cumplimiento de nuestro protocolo de PAP. Materiales y métodos: Se recogieron datos epidemiológicos, clínicos y microbiológicos en procedimientos consecutivos de MNQVB realizados en pacientes pediátricos (< 18 años) en nuestro centro (2010-2019). Resultados: Se incluyeron 113 procedimientos en 37 pacientes, con una mediana de edad de 4 años (RIC 1-8). Las principales enfermedades subyacentes fueron atresia biliar (32%) y cáncer (14%). El 68% se había sometido a un trasplante de hígado y el 70% a una hepaticoyeyunostomía. En 44 procedimientos (39%), la intervención se realizó durante el transcurso de la infección y se mantuvo el tratamiento antibiótico recetado previamente. En los otros 69, la PAP estaba indicada específicamente para la MNQVB; la eficacia de los antibióticos aumentó del 35 al 100% después de junio de 2017. En total, se produjeron 32 infecciones relacionadas con la MNQVB (28%), principalmente en las primeras 24 h posteriores al procedimiento (72%); no se produjo ninguna muerte. Los patógenos causantes fueron bacilos gramnegativos (64%), cocos grampositivos (28%) y Candida spp. (8%). Los principales factores de riesgo relacionados fueron la hepaticoyeyunostomía, la obstrucción biliar y el trasplante de hígado.(AU)

Challenges in genetic diagnosis, co-occurrence of 22q11.2 deletion syndrome and Noonan syndrome.

Noonan syndrome (NS) is caused by pathogenic variants in genes involved in the RAS/MAPK pathway. On the other hand, 22q11.2 Deletion Syndrome (22q11.2DS) is caused by heterozygous microdeletion on chromosome 22q11.2. The clinical characteristics of both syndromes are expected to be relatively distinct, and, in fact, there is only one report of these syndromes occurring together, but on daily clinical practice and especially in early childhood phenotypes may overlap. In this study, we describe a patient with NS and 22q11.2DS features harboring a heterozygous 2.54 Mb deletion of chromosome 22q11.2 and a variant in LZTR1, c.1531G > A p.(Val511Met). In 1993, Wilson et al reported a patient with both 22q11.2DS and NS, proposing that probably more than one gene is deleted in the proband and that one of the deleted genes is responsible for Noonan's phenotype. In our patient, one of the deleted genes within the 22q11.2 region was the LZTR1 gene which was associated with NS in 2015. This case also highlights the importance of the long-term patients' follow-up to detect evolutionary changes that may appear in the phenotype and alerts clinicians of the co-occurrence of two syndromes that may manifest over time.

Infectious complications of non-surgical biliary tract manipulation in paediatric patients. Role of antibiotic prophylaxis.

BACKGROUND: Infections related to non-surgical manipulation of the biliary tract (NSMBT) are common events despite periprocedural antibiotic prophylaxis (PAP). Since June 2017, our local protocol has indicated a 24-h regimen of intravenous piperacillin-tazobactam for this purpose. OBJECTIVE: We aimed to describe the incidence and characteristics of NSMBT-related paediatric infections, define risk factors for their development, and analyse adherence to our PAP protocol. MATERIALS AND METHODS: Epidemiological, clinical, and microbiological data were collected in consecutive NSMBT procedures performed in paediatric patients (<18 years) in our centre (2010-2019). RESULTS: 113 procedures in 37 patients, median age 4 years (IQR 1-8), were included. Main underlying diseases were biliary atresia (32%) and cancer (14%). Sixty-eight percent had undergone liver transplant and 70% hepaticojejunostomy. In 44 procedures (39%), the intervention was performed during the course of infection and previously prescribed antibiotic treatment was maintained. In the other 69, PAP was specifically indicated for NSMBT; antibiotic adequacy increased from 35% to 100% after June 2017. In total, 32 NSMBT-related infections (28%) occurred, mainly in the first 24h post-procedure (72%); no deaths happened. Causative pathogens were Gram-negative rods (64%), Gram-positive cocci (28%), and Candida spp. (8%). Main related risk factors were hepaticojejunostomy, biliary obstruction, and liver transplant. CONCLUSIONS: NSMBT in children entails a significant infection risk, even under antibiotic prophylaxis, being hepaticojejunostomy the main risk factor. Infectious complications mainly occurred immediately after the procedure. After establishing a PAP protocol, 100% of interventions received appropriate prophylaxis, decreasing antibiotic exposure time and potentially, the length of hospital stay.

Amibiasis vulvar: caso clínico / Vulvar amebiasis: clinical case

La amibiasis genital causada por Entamoeba histolytica es una entidad clínica poco frecuente, aun en zonas donde la enfermedad es endémica, es por ello que informamos el caso de una mujer de 74 años de edad ingresada en el servicio de Ginecología de nuestro centro con lesión exofítica ulcerada cubierta por una secreción amarillo verdosa fétida que afectaba labios mayores, labios menores y pliegues genito crurales, con diagnóstico por biopsia de amibiasis vulvar. Recibió tratamiento con metronidazol con resolución completa de la lesión genital. El objetivo de la publicación de este caso es por lo poco frecuente de la patología y la escasa literatura sobre la misma que se puede encontrar(AU)

The genital amebiasis caused by histolytic Entamoeba is a rare clinical entity, even in areas where the disease is endemic, that is which is why report the case of a 74-year-old woman, admitted to the gynecology service medical center, ulcerated exophytic lesion, covered by a fetid greenish yellow discharge that affected labia majora, labia minora and genito crural folds with vulvar biopsy diagnosis of amebiasis. She was treated with metronidazole with complete resolution of genital injury. The aim of the publication is so little frequent of pathology and the scarce literature on it that can be found(AU)

Telarquia prematura en lactantes y preescolares: efecto de la dieta / Premature thelarche in infants and preschooler children: effect of the diet

Evaluar el efecto de las recomendaciones dietéticas en la regresión de la telarquia prematura en lactantes y preescolares (entre 3 meses y 5 años y 11 meses de edad). Se estudiaron 80 pacientes con diagnóstico de telarquia prematura divididas en: grupo A de 31 pacientes (con dieta exenta de productos avícolas, tubérculos y soya) y grupo B de 41 pacientes (sin dieta). Servicio de Ginecología Infantil y Juvenil. Hospital de Niños "Dr. JM de los Ríos". Caracas. No hubo diferencia estadísticamente significativa en la edad de las pacientes: grupos A y B respectivamente (31,56 ± 22,40 meses vs. 43,44 ± 26,47 meses; P = 0,09). No se obtuvo variación significativa entre los grupos con respecto a la longitud del útero, (25,32 ± 5,09 mm vs. 28,20 ± 6,69 mm; P = 0,09) y al volumen ovárico derecho (0,52 ± 0,33 cm³ vs. 0,79 ± 0,69 cm³, P = 0,09). Se encontró diferencia estadísticamente significativa en el volumen ovárico izquierdo (0,45 ± 0,29 cm³ vs. 0,91 ± 1,40 cm³; P = 0,01). Se encontró aumento en los niveles de FSH para la edad de las pacientes (3,27 ± 2,29 mUI/mL vs. 2,88 ± 1,74 mUI/mL; P = 0,50). Los niveles de LH se encontraron dentro de límites normales (0,50 ± 0,81 mUI/mL vs. 0,51 ± 0,57 mUI/mL; P = 0,05). Las cifras de estradiol resultaron ligeramente elevadas (16,60 ± 12,12 pg/mL vs. 16,44 ± 8,79 pg/mL P = 0,95). El tiempo de regresión fue menor en el grupo B: 16 ± 6,19 meses vs. 10,75 ± 1,75 meses; (P = 0,01). La dieta de restricción de productos avícolas, tubérculos y soya no resultó de utilidad en la regresión de la telarquia prematura en las pacientes incluidas en este estudio

To evaluate the effect of dietary restriction in the regression of premature thelarche in infants (3 months to 2 years old) and preschooler children (2 to 5 years and 11 months old). 80 patients with diagnostic of premature thelarche divided into: group A with 31 patients (with diet exempt of avian products, tubercles and soybean) and group B with 41 patients (without diet). Servicio de Ginecologia Infantil y Juvenil. Hospital de Niños "Dr. JM de los Rios". Caracas. There was no significative statistical difference in age of patients: groups A and B respectively (31.56 ± 22.40 months vs. 43.44 ± 26.47 months; P = 0.09). There was no significative variation between groups in uterus length (25.32 ± 5.09 mm vs. 28.20 ± 6.69 mm; P = 0.09) and right ovarian volume (0.52 ± 0.33 cm³ vs. 0.79 ± 0.69 cm³, P = 0,09). There was a significative statistical difference in left ovarian volume (0.45 ± 0.29 cm³ vs. 0.91 ± 1.40 cm³; P = 0.11). An increase of FSH levels for age of patients was found (3.27 ± 2.29 mUI/mL vs. 2.88 ± 1.74 mUI/mL; P = 0.50). LH levels were within normal limits (0.50 ± 0.81 mUI/mL vs. 0.51 ± 0.57 mUI/mL; P = 0.96). Estradiol values resulted lightly increased (16.60 ± 12.12 pg/mL vs. 16.44 ± 8.79 pg/mL P = 0.95). The regression time was shorter in the group B: 16 ± 6.19 months vs. 10.75 ± 1.75 months; (P = 0.01). The diet with restriction of avian products, tubercles and soybean was no useful in the regression of premature thelarche in the patients included in this study